KDELR2 and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		KDELR2	MAP2K3
Description		KDEL endoplasmic reticulum protein retention receptor 2	mitogen-activated protein kinase kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cis-Golgi Network Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Membrane	Nucleoplasm Cytosol Membrane
	Molecular Function	KDEL Sequence Binding ER Retention Sequence Binding	MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Protein Retention In ER Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport	MAPK Cascade Regulation Of Cytokine Production Inflammatory Response Signal Transduction Peptidyl-tyrosine Phosphorylation Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction Cellular Senescence
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs			Fostamatinib
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Blood protein levels ( 29875488) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)
Interacting Genes		22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2	54 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		11014	5606
HPRD ID		06598	03816
Ensembl ID		ENSG00000136240	ENSG00000034152
Uniprot IDs		A0A024QZT7 P33947	P46734 Q6FI23
PDB IDs
Enriched GO Terms of Interacting Partners?
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