CCDC85B and PSMF1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
HPRD (two hybrid)

		CCDC85B	PSMF1
Description		coiled-coil domain containing 85B	proteasome inhibitor subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Adherens Junction	Nucleoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Delta-catenin Binding	Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Proteasome Binding
	Biological Process	Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Neonatal white matter microstructure ( 33009551)
Interacting Genes		138 interacting genes: AGGF1 AKAP17A AKIRIN2 APEX2 AQP1 BEX2 BEX3 BIRC5 C19orf25 C21orf91 C2CD6 C7orf50 C8orf48 CARD9 CCDC112 CCDC116 CCDC120 CCDC185 CCDC33 CCNK CDK18 CDKN1A CENPP CEP70 CFAP53 CHCHD3 COPS4 CWC25 DEPP1 DEUP1 DOK5 DTNB DUSP13 EIF3H ENKD1 EPS8 EXOC7 EXOC8 EZH2 FAM107A FAM124B FAM13C FAM214B FAM27E3 FAM50B FAM74A4 FASTKD5 FBF1 FCHSD2 FNDC11 FXR2 GCC1 GFI1B GPANK1 HMG20B HNRNPC IKZF5 INO80B KANSL1 KIAA0408 KRT17 KRT18 KRT20 KRT6A LDOC1 LMO3 LNX1 LZTS2 MBIP MCM10 MCRS1 MEAF6 MOAP1 MOB1A MOB4 NDUFA5 NEK6 NIF3L1 NRIP1 NUP54 ODAD4 PBXIP1 PIDD1 PKN1 PLEKHF2 PLOD3 POLR2L PRC1 PRPF3 PSMA1 PSMC1 PSMC6 PSMF1 RALYL RBM41 RBM7 RGS8 RIBC2 RNF8 SCNM1 SETD5 SF3A3 SIX1 SLU7 SMARCD1 SPATA46 SYT17 SYTL4 TASOR2 TCEANC TCHP TEAD4 THAP7 TNNI1 TNNT1 TSPYL4 TTC14 TUBGCP4 USP2 UTP14A UTP6 VPS72 ZBTB16 ZBTB5 ZC2HC1C ZFC3H1 ZFP36 ZNF165 ZNF205 ZNF250 ZNF337 ZNF417 ZNF426 ZNF564 ZNF587 ZNF638 ZNF764 ZNF821	36 interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 PSMA7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2
Entrez ID		11007	9491
HPRD ID		16101	17919
Ensembl ID		ENSG00000175602	ENSG00000125818
Uniprot IDs		Q15834	A0A140VJT2 B4DXW9 Q5QPM7 Q92530
PDB IDs			2VT8 4OUH
Enriched GO Terms of Interacting Partners?
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