YWHAQ and DAB2IP

Number of citations of the paper that reports this interaction (PubMedID 17389591)
37

Data Source:
BioGRID (pull down, affinity chromatography technology)

		YWHAQ	DAB2IP
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	DAB2 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Endocytic Vesicle Axon Dendrite Neuronal Cell Body Membrane Neuronal Cell Body Cerebellar Mossy Fiber Climbing Fiber Parallel Fiber AIP1-IRE1 Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding Protein N-terminus Binding 14-3-3 Protein Binding	GTPase Activator Activity Death Receptor Binding Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Phosphatidylinositol-3-phosphate Binding Signaling Adaptor Activity Toll-like Receptor 4 Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Protein-containing Complex Binding Cadherin Binding Protein Phosphatase 2A Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding
	Biological Process	Protein Targeting Signal Transduction Small GTPase Mediated Signal Transduction Substantia Nigra Development Cellular Protein Localization Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Negative Regulation Of Protein Phosphorylation Inflammatory Response Cell Cycle I-kappaB Phosphorylation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of GTPase Activity Cellular Response To Unfolded Protein Tube Formation Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Reelin-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Fibroblast Proliferation Neuron Projection Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synapse Maturation Positive Regulation Of Dendrite Development Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Migration Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors	Regulation of RAS by GAPs
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Abdominal aortic aneurysm ( 27899403 20622881) Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Arterial stiffness index ( 31235810) Coronary artery disease ( 32469254 29212778 33020668) Heart rate ( 23534349) Hip index ( 34021172) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Myocardial infarction ( 33532862) Periodontal microbiota ( 22699663) Squamous cell lung carcinoma ( 31326317) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		240 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ARHGEF2 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 IQGAP1 IRS2 ITCH ITGB4 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	7 interacting genes: AKT1 ANKS1A DAB1 DAB2 MAP3K5 SMARCA2 YWHAQ
Entrez ID		10971	153090
HPRD ID		00886	09903
Ensembl ID		ENSG00000134308	ENSG00000136848
Uniprot IDs		P27348	Q5VWQ8
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?
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