YIF1A and APOA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		YIF1A	APOA5
Description		Yip1 interacting factor homolog A, membrane trafficking protein	apolipoprotein A5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Integral Component Of Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Enzyme Activator Activity Heparin Binding Lipid Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Lipid Transport Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Regulation Of Intestinal Cholesterol Absorption Cholesterol Efflux Phospholipid Efflux Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Lipoprotein Lipase Activity Acylglycerol Homeostasis Triglyceride Homeostasis
Pathways		XBP1(S) activates chaperone genes	PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Glucose homeostasis traits ( 25524916)	Abdominal aortic aneurysm ( 32981348) Apolipoprotein A1 levels ( 32203549) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488) Body mass index ( 31978080) Cardiovascular risk factors (age interaction) ( 20838585) Carotenoid and tocopherol levels ( 19185284) Cholesterol, total ( 19060911 26780889 20686565) Coronary artery disease ( 32469254 29263402 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 28371326 20864672 19060906 21347282 26780889 20686565 26582766 29212154) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 31694877 28334899 26690388) Hematocrit ( 29403010) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733 33339817) Hypertriglyceridemia ( 31910446 27599772 23505323 20657596) LDL cholesterol ( 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095 24023260) Low HDL-cholesterol levels ( 31910446) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31910446 30382898 21386085 31170924 28371326 29212154) Metabolically unhealthy in normal weight ( 33500527) Metabolically unhealthy in obesity ( 33500527) Metabolite levels ( 23823483 22916037) Multiple sclerosis ( 31604244) NHDL cholesterol to HDL cholesterol ratio ( 28046027) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Platelet count ( 29403010) Postprandial triglyceride levels ( 32603185) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 29403010 29615537 30275531) Triacylglyceride levels ( 31551469) Triglyceride levels ( 30718733 28334899 26763881 32154731 28371326 29403010 33339817 29615537 32335043 29212154) Triglyceride levels in HIV infection ( 33109212) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 24097068 19074352 29404214 21909109 18193043 18193044 20864672 26160806 19060906 19060911 22171074 20139978 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)
Interacting Genes		82 interacting genes: ADAM17 APOA5 AQP6 BNIP2 C4orf3 CD79A CDK2AP2 CERS2 CNRIP1 CST6 EBP ELOVL4 ERGIC3 FAM210B FARS2 FCER1G FFAR2 GAS7 GJA8 GNL1 GPR37 GPR42 GPX8 HEATR1 JOSD2 KAT5 KCNK5 LNPK LSS MARCHF5 MGST3 MIEF2 MLLT1 MMGT1 MRPL18 MSMO1 MTERF3 MYG1 NDRG4 PLEKHF2 PPIF PRIM1 PTGES PTPN9 RBFA REEP2 REEP4 RIC3 RNF144A SCN3B SCN4B SDCBP SEC23IP SLC10A1 SLC34A1 SLC35C2 SLCO2B1 SNX10 SNX11 SNX2 STARD10 STIP1 SYTL2 SYTL5 TIMMDC1 TMEM139 TMEM14B TMEM17 TMEM225B TMEM248 TMEM31 TMX2 VKORC1 VMA21 WDFY2 WDR74 YIPF4 YIPF5 ZDHHC16 ZDHHC17 ZFYVE21 ZFYVE27	17 interacting genes: ACSF2 BMP10 CMTM3 CMTM5 CMTM6 FAS GRM3 MORN4 MYG1 RAB5B SELENOS SMARCD1 TMEM120B TMEM19 TMEM43 TTPA YIF1A
Entrez ID		10897	116519
HPRD ID		06755	06966
Ensembl ID		ENSG00000174851	ENSG00000110243
Uniprot IDs		A6NGW1 A8K509 O95070	A0A0B4RUS7 Q6Q788
PDB IDs
Enriched GO Terms of Interacting Partners?
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