MALT1 and FEM1C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MALT1	FEM1C
Description		MALT1 paracaspase	fem-1 homolog C
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GO Annotations	Cellular Component	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protease Binding Endopeptidase Activity Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Kinase Activator Activity Identical Protein Binding Protein Self-association	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	B-1 B Cell Differentiation Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of T-helper 17 Cell Differentiation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway	Neddylation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 21833088)	Conotruncal heart defects (inherited effects) ( 28468790) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		16 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RAB8A RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2	8 interacting genes: BCL2L11 CEP63 DCP2 LZTS2 MALT1 MCM8 PNMA1 RPGRIP1
Entrez ID		10892	56929
HPRD ID		06892	16384
Ensembl ID		ENSG00000172175	ENSG00000145780
Uniprot IDs		A8K5S1 Q9UDY8	Q96JP0
PDB IDs		2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9 7A41 7AK0 7AK1	6LBG 6LBN 6LDP 6LE6 6LEN 6LEY 6LF0 6XKC 7JYA
Enriched GO Terms of Interacting Partners?
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