NEK6 and ZC2HC1C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NEK6	ZC2HC1C
Description		NIMA related kinase 6	zinc finger C2HC-type containing 1C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite
	Molecular Function	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)	Neurociticism ( 29500382) Refractive error ( 32231278)
Interacting Genes		119 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 C5 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEP76 CFP CIR1 COG6 CTBP2 DDIT4L DES DPH2 EFHC2 EML4 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TEX45 TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1	80 interacting genes: ACTN2 ANKS1A ARMC7 BANP BICD2 BYSL C19orf54 CABP5 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC85B CCDC88B CIB3 CLIC3 CRACR2A DDX6 EMILIN1 ENKD1 FAM90A1 FBXO7 FGFR1OP2 FSD2 GFAP GOLGA1 GOLGA2 GOLGA6A GPRASP2 HOOK2 HSF2BP KASH5 KAT5 KATNBL1 KIF9 KRT15 KRT20 KRT40 LMNA LMNB2 LZTS2 MAPK9 MAPRE3 MID2 MTUS2 NCKIPSD NDEL1 NDOR1 NEK6 NOXA1 NTAQ1 OSGIN1 PFDN5 PIBF1 PNMA1 POLR1C PRKAB2 PSTPIP1 RABGEF1 RAD51D RINT1 SFN SIKE1 SMARCD1 SORBS3 SPAG5 TFIP11 TNPO2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM55 TRIM63 UBASH3A VPS52 ZNF655 ZNF76
Entrez ID		10783	79696
HPRD ID		05348	16607
Ensembl ID		ENSG00000119408	ENSG00000119703
Uniprot IDs		A0A024R8A6 Q9HC98	A0A024R6E6 H0YE08 J3KMY6 Q53FD0
PDB IDs
Enriched GO Terms of Interacting Partners?
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