PLK4 and SPAG5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLK4	SPAG5
Description		polo like kinase 4	sperm associated antigen 5
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome	Kinetochore Cytoplasm Cytosol Nuclear Body Midbody Centriolar Satellite Ciliary Rootlet Microtubule Plus-end Ciliary Basal Body Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity	Protein Binding Microtubule Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Cilium Assembly Trophoblast Giant Cell Differentiation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Positive Regulation Of Intracellular Transport Establishment Of Spindle Orientation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Centrosome Regulation Of Metaphase Plate Congression Positive Regulation Of Spindle Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39	58 interacting genes: AMOTL2 ARNT2 ATN1 BARD1 C1orf109 CCDC33 CCHCR1 CDC20B CDK1 CENPH CHCHD3 DCX EIF4E2 EIF4ENIF1 ENKD1 FBXO28 FMR1 GEM GOLGA8EP GOLGA8F HAUS1 IGFN1 IQCE KANSL1 KRT3 KRT75 LGALS14 LINGO1 MID1 MID2 NEBL NLGN3 ODF1 ORC6 PIMREG PKN1 PLK4 POLR2L POM121 RBM41 SH2D4A SHANK3 SMARCA2 SMARCE1 SNAP47 SNAPIN SPAG5-AS1 TSC1 TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZFYVE26 ZGPAT ZMAT2 ZNF385C ZNF572 ZNF688
Entrez ID		10733	10615
HPRD ID		10387	10246
Ensembl ID		ENSG00000142731	ENSG00000076382
Uniprot IDs		O00444	Q96R06
PDB IDs		2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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