CFL1 and MYCBP2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		CFL1	MYCBP2
Description		cofilin 1	MYC binding protein 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Membrane Axon Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Actin Filament Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Cell Motility Actin Filament Severing Establishment Of Spindle Localization Regulation Of Dendritic Spine Morphogenesis	Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Neuromuscular Process Regulation Of Cytoskeleton Organization Regulation Of Axon Guidance
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Dodecyldimethylamine N-oxide Copper Artenimol
Diseases
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		46 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CD5 CFL2 CLCN5 EGFR ERBB2 ERBB3 ERBB4 ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP MYCBP2 NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UBE2M UCHL5 WDR1 YWHAG YWHAQ YWHAZ	52 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 ATP1B3 CALM1 CD81 CDC14B CFL1 COMMD6 CUEDC2 DACH1 DHRS4L2 EDNRB ERBB3 FBXL3 FBXO45 FHL3 FSCN1 HSP90AB1 IGFBP6 LDHB LSM14A MAST3 MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 SCEL SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ
Entrez ID		1072	23077
HPRD ID		03261	10104
Ensembl ID		ENSG00000172757	ENSG00000005810
Uniprot IDs		P23528 V9HWI5	O75592
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO	5O6C 6T7F
Enriched GO Terms of Interacting Partners?
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