USP39 and SIRT7

Number of citations of the paper that reports this interaction (PubMedID 32711345)
3

Data Source:
BioGRID (enzymatic study)

		USP39	SIRT7
Description		ubiquitin specific peptidase 39	sirtuin 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Chromatin Nucleus Nucleoplasm Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Deacetylase Activity NAD-dependent Protein Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific) Protein-propionyllysine Depropionylase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle RNA Splicing Protein Deubiquitination Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Protein Deacetylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription Involved In Exit From Mitosis Homologous Chromosome Pairing At Meiosis RRNA Transcription Negative Regulation Of Transposition Regulation Of Mitochondrion Organization Histone Modification Negative Regulation Of Protein Ubiquitination Peptidyl-lysine Desuccinylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Export From Nucleus Protein Deglutarylation Peptidyl-lysine Deglutarylation R-loop Disassembly Histone H3 Deacetylation Histone H4 Deacetylation Protein Depropionylation Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Glutamine Methylation Positive Regulation Of RRNA Processing Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Neurofibrillary tangles ( 31497858)
Interacting Genes		16 interacting genes: ACVR1 APP CHEK2 LMAN2L LRRK2 SAE1 SIRT7 SP1 SRPK1 SRPK2 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8	12 interacting genes: APP DDB1 H2AC20 H2BC21 H3C1 H4C1 KAT2B MAGED1 POLR1E RRP9 USP39 WDR77
Entrez ID		10713	51547
HPRD ID		07165	12094
Ensembl ID		ENSG00000168883	ENSG00000187531
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	Q9NRC8
PDB IDs		3JCR 6AH0 6QW6 6QX9	5IQZ 6G0S
Enriched GO Terms of Interacting Partners?
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