CD226 and DOK6

		CD226	DOK6
Description		CD226 molecule	docking protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft	Cytoplasm Cytosol
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Interferon-gamma Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	RET signaling
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic widespread musculoskeletal pain ( 33331911) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 22139419 19820697 31194788 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763 27992413) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 33272962) Type 1 diabetes ( 21829393 25751624 17554260) White blood cell count ( 32888494)	Bone fracture in osteoporosis ( 28580392) Caudate activity during reward ( 28927378) Mean platelet volume ( 31194788) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Osteoporosis-related phenotypes ( 20548944) Platelet distribution width ( 32888494) Pursuit maintenance gain ( 29064472) Response to cytidine analogues (gemcitabine) ( 24483146) Skin aging (microtopography measurement) ( 28502801)
Interacting Genes		8 interacting genes: CNDP2 DOK6 FYN GALR1 ITGB2 NECTIN2 PVR TSHZ1	21 interacting genes: ABHD11 ARID5A C1orf94 CD226 CRYBB3 EGFR ERBB2 FAM86C1P LASP1 LGALS14 METTL27 NTRK3 PRR22 RBPMS RET RUSC1 SLC30A6 TBX15 TLE5 USP54 YPEL3
Entrez ID		10666	220164
HPRD ID		09252	13244
Ensembl ID		ENSG00000150637	ENSG00000206052
Uniprot IDs		J3QR77 Q15762	Q6PKX4
PDB IDs		6ISB 6O3O
Enriched GO Terms of Interacting Partners?
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