RBCK1 and MKRN2

Number of citations of the paper that reports this interaction (PubMedID 22493164)
7

Data Source:
BioGRID (two hybrid)

		RBCK1	MKRN2
Description		RANBP2-type and C3HC4-type zinc finger containing 1	makorin ring finger protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	RNA Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Biological_process Protein Ubiquitination
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Hip index ( 34021172) Monocyte percentage of white cells ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		64 interacting genes: APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414	15 interacting genes: C1orf109 CLK1 EIF3F IGF2BP3 MRPS25 NDN PALS2 PDLIM2 RACK1 RBCK1 RELA UBE2D1 UBE2D4 UBE2K UBE2L3
Entrez ID		10616	23609
HPRD ID		16643	09761
Ensembl ID		ENSG00000125826	ENSG00000075975
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	Q9H000
PDB IDs		2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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