SMC2 and SMC4

Number of citations of the paper that reports this interaction (PubMedID 9789013)
39

Data Source:
HPRD (in vitro, in vivo)

		SMC2	SMC4
Description		structural maintenance of chromosomes 2	structural maintenance of chromosomes 4
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome	Chromosome, Centromeric Region Condensin Complex Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding
	Biological Process	Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization	Mitotic Sister Chromatid Segregation Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203 33549134) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Malaria ( 31844061)
Interacting Genes		12 interacting genes: ABCC5 CDC42 DISC1 DNMT3B ERP44 GULP1 LIG4 NCAPD2 PTEN SMC4 SUMO2 TRAF3IP1	5 interacting genes: NCAPD2 PTEN SMC2 SUMO2 TRAF3IP1
Entrez ID		10592	10051
HPRD ID		09277	09276
Ensembl ID		ENSG00000136824	ENSG00000113810
Uniprot IDs		A0A024R158 A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	B3KXX5 E9PD53 Q58F29 Q9NTJ3
PDB IDs		4U4P	4U4P
Enriched GO Terms of Interacting Partners?
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