LAMTOR5 and SHB

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		LAMTOR5	SHB
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	SH2 domain containing adaptor protein B
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Protein-containing Complex Ragulator Complex	Nucleoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Phosphotyrosine Residue Binding Protein Binding
	Biological Process	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Angiogenesis Apoptotic Process Signal Transduction Cell Differentiation
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		65 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLCC1 CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LAMTOR4 LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	28 interacting genes: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 FGFR1 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70
Entrez ID		10542	6461
HPRD ID		09773	02635
Ensembl ID		ENSG00000134248	ENSG00000107338
Uniprot IDs		A0A0C4DGV4 O43504	Q15464
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?