ATG7 and GABARAP

Number of citations of the paper that reports this interaction (PubMedID 16303767)
74

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ATG7	GABARAP
Description		autophagy related 7	GABA type A receptor-associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Extracellular Region Cytoplasm Cytosol Axoneme Axon Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Golgi Membrane Autophagosome Membrane Lysosome Autophagosome Smooth Endoplasmic Reticulum Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Actin Cytoskeleton Cytoplasmic Vesicle Cell Body Synapse Perinuclear Region Of Cytoplasm Sperm Midpiece
	Molecular Function	Protein Binding Transcription Factor Binding Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Protein Lipidation C-terminal Protein Lipidation Autophagy Cellular Response To Nitrogen Starvation Aging Cellular Response To Starvation Response To Glucose Positive Regulation Of Autophagy Protein Transport Macroautophagy Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Piecemeal Microautophagy Of The Nucleus Suppression By Virus Of Host Autophagy Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Late Nucleophagy Positive Regulation Of Protein Catabolic Process Rhythmic Process Defense Response To Virus Chaperone-mediated Autophagy Cellular Response To Morphine Cellular Response To Hyperoxia Positive Regulation By Symbiont Of Host Autophagy Negative Regulation Of Mitochondrial DNA Replication Response To Fluoride Negative Regulation Of Oxidative Stress-induced Neuron Death	Autophagosome Assembly Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Protein Targeting Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Positive Regulation Of Protein K48-linked Ubiquitination
Pathways		Macroautophagy Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF1 fusions Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat mass ( 28552196) Body size at age 10 ( 32376654) Circulating chemerin levels ( 25521368) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) Relative hand skill in reading disability ( 24068947) Small vessel stroke ( 29123153) Systolic blood pressure ( 27618447 27618452 30578418) Waist-to-hip ratio adjusted for BMI ( 34021172)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		10 interacting genes: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B	61 interacting genes: AMBRA1 ANK2 ANK3 ATG101 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 ATXN3 BIRC6 CUL3 DMPK DVL2 FLCN GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAPK15 MEFV MIB1 MLH1 MPC1 MYBPC2 NBR1 NEDD4 NEK9 NSF OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 SEC62 SNX18 SQSTM1 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TP53INP1 TRIM21 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28
Entrez ID		10533	11337
HPRD ID		12293	05496
Ensembl ID		ENSG00000197548	ENSG00000170296
Uniprot IDs		B3KQM6 O95352	O95166 Q6IAW1
PDB IDs			1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 7BRQ 7BRT 7BRU 7BV4
Enriched GO Terms of Interacting Partners?
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