APPBP2 and GALNT3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		APPBP2	GALNT3
Description		amyloid beta precursor protein binding protein 2	polypeptide N-acetylgalactosaminyltransferase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Calcium Ion Binding Manganese Ion Binding Carbohydrate Binding
	Biological Process	Intracellular Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Carbohydrate Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway O-glycan Processing Protein O-linked Glycosylation Via Serine Protein O-linked Glycosylation Via Threonine
Pathways			FGFR3c ligand binding and activation Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	Bone mineral density ( 21533022) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Lumbar spine bone mineral density ( 22504420) Serum alkaline phosphatase levels ( 33547301) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		120 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ATP13A1 BCL7A BIN2 C1orf50 C6orf226 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MFSD3 MGAT4B MLLT3 MMP28 MSH2 MSLN MUL1 MYLK NFYA NPRL3 PCSK5 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC7A10 SLC9A3R1 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	3 interacting genes: APPBP2 LRP2 MAPK8IP2
Entrez ID		10513	2591
HPRD ID		05616	03453
Ensembl ID		ENSG00000062725	ENSG00000115339
Uniprot IDs		A0A024QZ47 Q92624	Q14435
PDB IDs
Enriched GO Terms of Interacting Partners?
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