SEC23A and TNFSF14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SEC23A	TNFSF14
Description		SEC23 homolog A, COPII coat complex component	TNF superfamily member 14
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Extrinsic Component Of Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Intracellular Protein Transport Regulation Of Catalytic Activity Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Antigen Presentation: Folding, assembly and peptide loading of class I MHC	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Vitamin D levels ( 29343764)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)
Interacting Genes		36 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MEF2C MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23B SEC23IP SEC24B SEC24C SEC24D SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11	25 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP S1PR4 SEC22A SEC23A SLC38A3 SYS1 TCF3 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		10484	8740
HPRD ID		06714	05157
Ensembl ID		ENSG00000100934	ENSG00000125735
Uniprot IDs		Q15436	O43557
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO	4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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