TUBGCP3 and CDC16

		TUBGCP3	CDC16
Description		tubulin gamma complex associated protein 3	cell division cycle 16
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GO Annotations	Cellular Component	Equatorial Microtubule Organizing Center Gamma-tubulin Complex Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Gamma-tubulin Small Complex Membrane	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Gamma-tubulin Binding Microtubule Minus-end Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Microtubule Nucleation Single Fertilization Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle	Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
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Diseases
GWAS		Glycated hemoglobin levels ( 20858683)	Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		11 interacting genes: AKAP9 ARTN CDC16 DNAJB6 IMMT LRBA PCNT PROZ RASA3 TUBG1 TUBG2	25 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC26 CDC27 DAB2 DNAJA1 FBXO5 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 TUBGCP3 UBE2S XRCC5
Entrez ID		10426	8881
HPRD ID		10289	04587
Ensembl ID		ENSG00000126216	ENSG00000130177
Uniprot IDs		A0A087WU06 B4DYP7 Q96CW5	A0A024RDZ2 A0A3B3ISD2 B2RCW0 Q13042
PDB IDs		6V6B 6V6S 6X0U 7AS4	3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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