PRMT5 and EIF4A1

Number of citations of the paper that reports this interaction (PubMedID 33020149)
0

Data Source:
BioGRID (pull down)

		PRMT5	EIF4A1
Description		protein arginine methyltransferase 5	eukaryotic translation initiation factor 4A1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Histone Methyltransferase Complex	Nucleus Cytoplasm Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Exosome
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity E-box Binding	RNA Cap Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding ATP Hydrolysis Activity
	Biological Process	Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation Regulation Of DNA Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway	Cytoplasmic Translational Initiation
Pathways		snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Copper
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		93 interacting genes: ARGLU1 C1orf109 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A CTDP1 DIO3 DNMT3A DUSP14 EIF4A1 EIF4A3 ELOA EPHB6 EZH2 FAM76B GAS8 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H3C1 H4-16 H4C1 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NCL NELFCD NTAQ1 NUDCD2 OLA1 PDCD4 PDGFRA PHYHIP POLR2A PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 STUB1 SUPT5H TRIB3 TRIM54 TYK2 UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1	18 interacting genes: EIF4G1 EIF4G2 EIF4G3 FAM107A LIG4 MAPK6 MYH10 OGT PAIP1 PDCD4 PLPPR4 PRMT1 PRMT5 SUMO2 TNKS UCHL5 UPF2 WDR77
Entrez ID		10419	1973
HPRD ID		04955	04030
Ensembl ID		ENSG00000100462	ENSG00000161960
Uniprot IDs		B4DV00 O14744	P60842
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P	2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW
Enriched GO Terms of Interacting Partners?
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