NDRG1 and HSD17B4

Number of citations of the paper that reports this interaction (PubMedID 17220478)
24

Data Source:
HPRD (in vivo)

		NDRG1	HSD17B4
Description		N-myc downstream regulated 1	hydroxysteroid 17-beta dehydrogenase 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Protein Binding Microtubule Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Enoyl-CoA Hydratase Activity Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Postsynapse Organization	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Fatty Acid Beta-oxidation Androgen Metabolic Process Estrogen Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Sertoli Cell Development
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs			NADH (R)-3-hydroxydecanoyl-CoA
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) JT interval (sulfonylurea treatment interaction) ( 27958378) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		72 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN GPAA1 GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TFAP2B TLE3 UPF1 VCP XRCC5 ZNF155	8 interacting genes: ACTB BAK1 CASP9 CDK7 FER MAPK8 NDRG1 SNCA
Entrez ID		10397	3295
HPRD ID		05586	03514
Ensembl ID		ENSG00000104419	ENSG00000133835
Uniprot IDs		B3KWB2 Q8N959 Q92597	A0A0S2Z4J1 B2R659 B3KSP2 P51659
PDB IDs		6ZMM	1IKT 1S9C 1ZBQ 6Z1W 6Z1X
Enriched GO Terms of Interacting Partners?
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