DLC1 and PPP3R2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		DLC1	PPP3R2
Description		DLC1 Rho GTPase activating protein	protein phosphatase 3 regulatory subunit B, beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Caveola Focal Adhesion Cortical Actin Cytoskeleton Ruffle Membrane Membrane Raft
	Molecular Function	GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding	Calcium Ion Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity
	Biological Process	Neural Tube Closure Heart Morphogenesis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Dephosphorylation Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis	Regulation Of Catalytic Activity
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle
Drugs			Cyclosporine Voclosporin
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels in HIV infection ( 33109212) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Platelet distribution width ( 32888494) PR interval ( 32439900) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)
Interacting Genes		36 interacting genes: ACOT7 AKT1 AOPEP BAAT CCDC180 CDC14B CORO2A CTSV FANCC FBP2 HEMGN HSD17B3 MAPK3 PFKM PKM PPP3R2 PTEN RANGAP1 RASA1 RHOA RPS6KA1 SFRP4 SMAD1 SOX7 STX17 TDRD7 TGFB1 TMEFF1 TMEM129 TMOD1 TNS2 TRMO USP4 XPA ZNF189 ZNF510	20 interacting genes: APC AURKA BUB1 CCND1 CD14 DLC1 DYNLL1 ERP44 FBXW7 KRT34 MLH3 MSH2 PDGFRL PPP3CA PTPN12 PTPRJ RAB32 SMAD4 TBC1D10C TFCP2
Entrez ID		10395	5535
HPRD ID		05035	10164
Ensembl ID		ENSG00000164741	ENSG00000188386
Uniprot IDs		A8K119 Q96QB1	Q96LZ3
PDB IDs		2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT
Enriched GO Terms of Interacting Partners?
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