MAEA and UBE2R2

Number of citations of the paper that reports this interaction (PubMedID 29911972)
27

Data Source:
BioGRID (enzymatic study)

		MAEA	UBE2R2
Description		macrophage erythroblast attacher, E3 ubiquitin ligase	ubiquitin conjugating enzyme E2 R2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Spindle Actomyosin Contractile Ring Cytoskeleton Integral Component Of Plasma Membrane Nuclear Matrix GID Complex	Cytosol
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cytoskeleton Organization Cell Cycle Cell Adhesion Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Myeloid Cell Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Enucleate Erythrocyte Development Cell Division	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein K48-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Tetrachlorodecaoxide
Diseases
GWAS		Fasting glucose ( 34059833) Obesity-related traits ( 23251661) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969 26818947 23945395 32499647 22158537 30718926 28869590)	Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ARMC8 GID4 GID8 GSK3A MKLN1 MYOC RANBP10 RMND5A UBE2D3 UBE2H UBE2R2	26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC
Entrez ID		10296	54926
HPRD ID		08427	15602
Ensembl ID		ENSG00000090316	ENSG00000107341
Uniprot IDs		B3KRN7 B4DJP8 B4DQT1 B4DVN3 D6RIB6 Q7L5Y9	Q712K3
PDB IDs			6NYO
Enriched GO Terms of Interacting Partners?
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