CDKN1B and UCHL1

Number of citations of the paper that reports this interaction (PubMedID 12082530)
25

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		CDKN1B	UCHL1
Description		cyclin dependent kinase inhibitor 1B	ubiquitin C-terminal hydrolase L1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin Binding Hsp70 Protein Binding Protein-containing Complex Binding Chaperone Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Response To Hypoxia Placenta Development Potassium Ion Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Exit From Mitosis Notch Signaling Pathway Heart Development Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Glucose Positive Regulation Of Cell Death Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Response To Estradiol Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Response To Amino Acid Response To Peptide Hormone Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Response To Cadmium Ion Autophagic Cell Death Inner Ear Development Negative Regulation Of Cellular Component Movement Regulation Of Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Cellular Senescence Regulation Of Lens Fiber Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Population Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	UCH proteinases
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 31562322 29892016) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568 33272962) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)	Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		73 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CDC34 CDK1 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL1 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RBX1 RCHY1 RNF123 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2I UBE2L3 UBE3A UCHL1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		1027	7345
HPRD ID		02867	01877
Ensembl ID		ENSG00000111276	ENSG00000154277
Uniprot IDs		P46527 Q6I9V6	P09936 V9HW74
PDB IDs		1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G 7B5L 7B5M 7B5R	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
Enriched GO Terms of Interacting Partners?
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