SPRY2 and CREB5

  • Number of citations of the paper that reports this interaction (PubMedID 25416956)
  • 484
  • Data Source:
  • BioGRID (two hybrid)

SPRY2

CREB5

Description sprouty RTK signaling antagonist 2 cAMP responsive element binding protein 5
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adolescent idiopathic scoliosis ( 31417091)
  • Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325)
  • Age-related cognitive decline (memory) (slope of z-scores) ( 30954325)
  • Airflow obstruction ( 22837378)
  • Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600)
  • Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728)
  • Anxiety in major depressive disorder ( 24047446)
  • Asthma ( 31959851)
  • Asthma (childhood onset) ( 31036433)
  • Atrial fibrillation ( 30061737 29892015)
  • Attention deficit hyperactivity disorder ( 18839057)
  • Basophil count ( 32888494)
  • Basophil percentage of white cells ( 32888494)
  • Blond vs. brown/black hair color ( 30531825)
  • Breast cancer ( 29059683)
  • Cataracts ( 34127677)
  • Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)
  • Crohn's disease ( 23128233)
  • Diabetic retinopathy ( 21441570)
  • Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
  • Eosinophil percentage of granulocytes ( 27863252)
  • Ferritin levels ( 33491795)
  • Granulocyte count ( 27863252)
  • Granulocyte percentage of myeloid white cells ( 27863252)
  • Hand grip strength ( 29691431)
  • Heel bone mineral density ( 30598549 28869591)
  • Height ( 28552196)
  • Hip circumference adjusted for BMI ( 34021172)
  • Lymphocyte percentage of white cells ( 32888494 27863252)
  • Monocyte count ( 32888494)
  • Monocyte percentage of white cells ( 32888494 27863252)
  • Myeloid white cell count ( 27863252)
  • Neutrophil count ( 29403010 32888494 27863252)
  • Neutrophil percentage of granulocytes ( 27863252)
  • Neutrophil percentage of white cells ( 32888494 27863252)
  • Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
  • Pre-treatment viral load in HIV-1 infection ( 31219150)
  • Pulse pressure ( 27841878 30578418)
  • Serum thyroid-stimulating hormone levels ( 25436638)
  • Smoking behaviour (cigarettes smoked per day) ( 31217584)
  • Sum basophil neutrophil counts ( 27863252)
  • Sum neutrophil eosinophil counts ( 27863252)
  • TPE interval (resting) ( 32386560)
  • Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
  • Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
  • White blood cell count ( 29403010 32888494 27863252)
  • White blood cell count (basophil) ( 27863252)
Interacting Genes 109 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 FXR1 FXR2 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NDFIP2 NEDD4 NR1H2 NUBP1 NUFIP2 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587 132 interacting genes: ADAMTSL4 AJUBA AKAP8L ALPP ANAPC11 ATF2 BATF3 CDPF1 CERCAM CIB4 CNFN COL8A1 CYP21A2 CYSRT1 EFEMP2 FBLN1 FHL3 FOS FOSB FOSL1 FOSL2 FRS3 FST HOXA1 HSD3B7 ID3 IGFBP6 INTS11 JDP2 JUN KIFC3 KPRP KRT15 KRT31 KRT40 KRT83 KRT85 KRT86 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP19-3 KRTAP19-5 KRTAP19-6 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1C LCE2A LCE2C LCE4A LCE5A LGALS13 LITAF LMX1B MDFI MGAT5B MLLT6 MMADHC MTUS2 NADSYN1 NBPF19 NOTCH2NLA PCSK5 PLA2G10 PRDM14 PRR22 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS20 RIMBP3 RNF144B RNF208 SIVA1 SNAPC5 SPATA12 SPOP SPOPL SPRED1 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D TP53BP1 TRAF2 TRIM23 TRIM27 TRIM42 TRIP6 TSGA10 TSPAN4 TSR2 UFSP1 UNKL WWOX ZMAT5 ZNF330
Entrez ID 10253 9586
HPRD ID 03916 09896
Ensembl ID ENSG00000136158 ENSG00000146592
Uniprot IDs O43597 Q02930
PDB IDs 3BUM 3OB1 5HKY 5HKZ 5HL0
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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