CDK7 and TAF7

Number of citations of the paper that reports this interaction (PubMedID 18391197)
23

Data Source:
BioGRID (pull down)

		CDK7	TAF7
Description		cyclin dependent kinase 7	TATA-box binding protein associated factor 7
Image
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Fibrillar Center Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cytoplasm Cytosol Plasma Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Perinuclear Region Of Cytoplasm CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Cytoplasm Transcription Factor TFTC Complex MLL1 Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding TFIIH-class Transcription Factor Complex Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Histone Acetyltransferase Binding Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Protein Heterodimerization Activity H3K27me3 Modified Histone Binding P-TEFb Complex Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Cell Division Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain	Negative Regulation Of Transcription By RNA Polymerase II Spermine Transport DNA-templated Transcription, Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Histone Acetylation Negative Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Negative Regulation Of Histone H4 Acetylation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs		Phosphonothreonine Alvocidib SNS-032 Seliciclib
Diseases
GWAS			Mean platelet volume ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		45 interacting genes: ADAMTS6 APP AR BRCA1 CCND2 CCNH CDC37 CDK1 CDK2 CDK6 CDK9 CTDP1 CUX1 E2F1 ERCC2 ERCC3 ESR1 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H5 H1-1 HLA-DQA1 HSD17B4 LASP1 MBP MCM7 MNAT1 NEK6 PCGF6 POLR2B PRKCI RARA SMAD1 SRPK1 SRPK2 SUPT5H TAF7 TCEA1 THRA TP53 UBE2D1 VDR	28 interacting genes: AHR CDK7 CDK9 CPSF1 FAU GATA1 H3-4 HSF1 IKBKG MAP1LC3B OGT RBM6 SETD7 TAF1 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF5 TAF6 TAF8 TAF9 TRIM22 TRIM24 YWHAE ZSCAN1
Entrez ID		1022	6879
HPRD ID		15993	07196
Ensembl ID		ENSG00000134058	ENSG00000178913
Uniprot IDs		A0A0S2Z3F9 D6R9G1 D6RFL0 P50613	Q15545
PDB IDs		1LG3 1PA8 1UA2 2HIC 6O9L 6XBZ 6XD3 7B5O 7B5Q	4RGW 5FUR 6MZL 6MZM
Enriched GO Terms of Interacting Partners?
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