PSMD14 and OLIG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PSMD14	OLIG1
Description		proteasome 26S subunit, non-ATPase 14	oligodendrocyte transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Lid Subcomplex Proteasome Accessory Complex Cytosolic Proteasome Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Chromatin Nucleus
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity Metal Ion Binding Endopeptidase Activator Activity Lys63-specific Deubiquitinase Activity Isopeptidase Activity Proteasome Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Endopeptidase Activity Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Ethanol Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination	Regulation Of Transcription By RNA Polymerase II Oligodendrocyte Development Neuron Differentiation Neuron Fate Commitment
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Educational attainment ( 25201988) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990)
Interacting Genes		11 interacting genes: ADRM1 DPY30 FAM9B IRF3 MEOX2 MITF OLIG1 PSMD7 TGFBR1 TGFBR2 UBE2V1	15 interacting genes: CACNA1A DOK4 DOK5 GRB2 HSH2D MRPL12 NCK1 NUMB PSMD14 PTPN6 RASA1 SH2D1A SH2D4A SHD STAT5A
Entrez ID		10213	116448
HPRD ID		06208	07333
Ensembl ID		ENSG00000115233	ENSG00000184221
Uniprot IDs		A0A140VKF2 O00487	Q8TAK6
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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