FEM1B and APAF1

Number of citations of the paper that reports this interaction (PubMedID 10764728)
12

Data Source:
HPRD (in vivo, in vitro)

		FEM1B	APAF1
Description		fem-1 homolog B	apoptotic peptidase activating factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex	Extracellular Region Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Death Receptor Binding Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	Response To Hypoxia Kidney Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Brain Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			ATP
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		8 interacting genes: APAF1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A TLE3	30 interacting genes: ACADS APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CCL13 CDK17 CYCS DZIP1 ELK3 FAS FEM1B HIP1 HNF1A HSP90AA1 HSPA1A MRPL19 NLRP1 NR1H4 NUDT4 PAH PPP1CA RPL26L1 TOP1 TRIAP1 UTP20
Entrez ID		10116	317
HPRD ID		16889	03755
Ensembl ID		ENSG00000169018	ENSG00000120868
Uniprot IDs		Q9UK73	O14727
PDB IDs		6LBF 7CNG	1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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