HIPK3 and RGS3

Number of citations of the paper that reports this interaction (PubMedID 15231748)
99

Data Source:
HPRD (two hybrid)

		HIPK3	RGS3
Description		homeodomain interacting protein kinase 3	regulator of G protein signaling 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body	Nucleus Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Protein Serine Kinase Activity	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Catalytic Activity
Pathways			G alpha (q) signalling events G alpha (i) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Anger ( 24489884) Obese vs. thin ( 30677029) Sleep (1/3-day periodicity) ( 33075057) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I WT1 ZNF107 ZYX	25 interacting genes: ACD APP CDK6 CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		10114	5998
HPRD ID		05111	03720
Ensembl ID		ENSG00000110422	ENSG00000138835
Uniprot IDs		A8KAE4 Q9H422	A0A024R831 A0A024R833 A0A024R841 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3
PDB IDs			2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?
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