ARPC2 and MDN1

		ARPC2	MDN1
Description		actin related protein 2/3 complex subunit 2	midasin AAA ATPase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Site Of Double-strand Break Muscle Cell Projection Membrane Neuron Projection Extracellular Exosome Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytosol Membrane Preribosome, Large Subunit Precursor Intermediate Filament Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Ribosomal Large Subunit Assembly RRNA Processing
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Inflammatory bowel disease ( 28067908 23128233) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) White blood cell count ( 25096241 29403010)	Asthma ( 31959851) Coronary artery disease ( 29212778) QRS interval (sulfonylurea treatment interaction) ( 27958378)
Interacting Genes		10 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B MDN1 NFE2L2 SHANK3 WAS ZYG11B	11 interacting genes: AKIRIN2 AR ARPC2 DOP1A E2F6 FADS3 PTEN SUMO2 UBC VCX ZNF292
Entrez ID		10109	23195
HPRD ID		10367	10069
Ensembl ID		ENSG00000163466	ENSG00000112159
Uniprot IDs		A0A024R408 O15144 Q53R19	Q9NU22
PDB IDs		6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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