DPP3 and FADS2

		DPP3	FADS2
Description		dipeptidyl peptidase 3	fatty acid desaturase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Dipeptidyl-peptidase Activity Zinc Ion Binding Metalloaminopeptidase Activity	Stearoyl-CoA 9-desaturase Activity Linoleoyl-CoA Desaturase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water
	Biological Process	Proteolysis	Lipid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process
Pathways			Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism alpha-linolenic acid (ALA) metabolism
Drugs			alpha-Linolenic acid
Diseases
GWAS		Bipolar disorder ( 21926972)	Alanine aminotransferase levels ( 33339817) Albumin-globulin ratio ( 29403010) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic valve stenosis ( 32186652) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Asthma ( 31959851 32296059 31619474) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 24097068 19060911 25961943 20686565) Cholesteryl ester levels ( 31551469) Colorectal cancer ( 24836286) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 28067908) Daytime nap ( 33568662) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Fatty acid desaturase activity (serum) ( 30453627) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 24647736 28898252) Glycerophospholipid levels ( 26068415) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 19060906 19060911 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 28869591) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) IgA levels ( 28628107) Inflammatory bowel disease ( 23128233) Iron status biomarkers (transferrin levels) ( 25352340) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 24097068 19060910 19060911 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer in ever smokers ( 28604730) Lymphocyte percentage of white cells ( 32888494) Lysophosphatidylcholine levels ( 31551469) Lysophosphatidylethanolamine levels ( 31551469) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 20694148 31589552) Metabolite levels ( 23823483 23378610 22916037) Metabolite levels (lipid measures) ( 27005778) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 32888494) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Oleic acid (18:1n-9) levels ( 28298293 23362303) P wave duration ( 24850809) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Phosphatidylcholine levels ( 31551469) Phosphatidylcholine-ether levels ( 31551469) Phosphatidylethanolamine levels ( 31551469) Phosphatidylethanolamine-ether levels ( 31551469) Phosphatidylinositol levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) PR interval ( 32439900) Pulse pressure ( 30578418) QRS duration ( 27659466) QT interval ( 24952745 29874175) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 29769521 27798624) Rheumatoid arthritis ( 30423114 24390342) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 31636271 33031748 23093944) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Sphingolipid levels ( 26068415 22359512) Sphingomyelin levels ( 31551469) Stearic acid (18:0) levels ( 23362303) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29403010 33339817) Triacylglyceride levels ( 31551469) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 32203549 28334899 32154731 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 19060906 25961943 20686565) Type 1 diabetes ( 34127860) Urate levels ( 31578528) Vaccenic acid (18:1n-7) levels ( 28298293) Vitiligo ( 27723757)
Interacting Genes		10 interacting genes: APP ATP5F1C FADS2 HSPA8 KEAP1 LIG4 POT1 TERF1 TERF2IP TINF2	15 interacting genes: ATXN1L CA7 DPP3 KRT31 KRT40 NBPF19 NOTCH2NLA PSG2 PYGM RAB3IL1 RAD51B SFRP4 SYT7 TMEM258 ZNF655
Entrez ID		10072	9415
HPRD ID		06012	05854
Ensembl ID		ENSG00000254986	ENSG00000134824
Uniprot IDs		Q5JPB8 Q9NY33	O95864
PDB IDs		3FVY 3T6B 3T6J 5E2Q 5E33 5E3A 5E3C 5EGY 5EHH
Enriched GO Terms of Interacting Partners?
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