SAE1 and UBD

Number of citations of the paper that reports this interaction (PubMedID 31575873)
6

Data Source:
BioGRID (pull down)

		SAE1	UBD
Description		SUMO1 activating enzyme subunit 1	ubiquitin D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity	Protein Binding Proteasome Binding
	Biological Process	Protein Ubiquitination Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Interferon-gamma Response To Tumor Necrosis Factor Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Aggresome Assembly Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Neddylation
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		22 interacting genes: AGTR1 APP CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39	14 interacting genes: MAD2L1 NUB1 OTUB1 PDE9A PSMD4 SAE1 SRPK1 SRPK2 TGFBR1 UBA2 UBA6 UBE2D2 UBE2Z USP16
Entrez ID		10055	10537
HPRD ID		18010	09354
Ensembl ID		ENSG00000142230	ENSG00000213886
Uniprot IDs		A0A024R0R4 Q9UBE0	A0A1U9X8S6 O15205
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ	2MBE 6GF1 6GF2
Enriched GO Terms of Interacting Partners?
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