SH2B3 and NCOR2

		SH2B3	NCOR2
Description		SH2B adaptor protein 3	nuclear receptor corepressor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcription Repressor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Stem Cell Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Protein Tyrosine Kinase Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein N-terminus Binding
	Biological Process	Neutrophil Homeostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Intracellular Signal Transduction Monocyte Homeostasis Megakaryocyte Development Cellular Response To Interleukin-3 Thrombopoietin-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Erythrocyte Development Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Negative Regulation Of Kit Signaling Pathway Cellular Response To Chemokine	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Lactation Response To Organonitrogen Compound Regulation Of Cellular Ketone Metabolic Process Response To Estradiol Estrous Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways		Regulation of KIT signaling Negative regulation of FLT3 Factors involved in megakaryocyte development and platelet production	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1
Drugs		Pazopanib
Diseases
GWAS		Addison's disease ( 33574239) Alanine aminotransferase levels ( 33547301 34315874) Allergic rhinitis ( 30013184) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 29273807) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 27736895 19430479 19430483 27841878 21909115 28739976 27618447 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 19198610 32888494) Fibrinogen levels ( 28107422 26561523) Gastroesophageal reflux disease ( 31527586) Glaucoma (multi-trait analysis) ( 31959993) Glycated hemoglobin levels ( 34059833) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494 27863252 28017375 19862010) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) IgA levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 31959993) Ischemic stroke ( 24262325 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Left ventricular end-diastolic volume ( 33495596 32382064) Left ventricular end-systolic volume ( 33495596) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 28017375) Mean corpuscular volume ( 28017375) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 26343387) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 22139419 24026423 33545615 32888494 25705162 20139978 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763 27992413) Reaction time ( 27046643) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 32723749 30423114 24390342 20453842) Sarcoidosis ( 26051272) Small vessel stroke (CCS or TOAST classification) ( 32047268) Small vessel stroke (CCSp classification) ( 32047268) Spleen volume ( 34128465) Stroke ( 29531354) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 19430479 27841878 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 27182965 28928442) Tumor necrosis factor levels ( 32805626) Type 1 diabetes ( 21829393 25751624 19430480 17554300 30572963) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 32499647) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Appendicular lean mass ( 33097823) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: BRAP CD247 EGFR ERBB2 ERBB3 ERBB4 FLNA GRB2 KIT LCK MET NCOR2 TNS2 VPS29 ZAP70	91 interacting genes: ADRB2 AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CDK2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG PTPN11 RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SH2B3 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16 ZBTB7A
Entrez ID		10019	9612
HPRD ID		05480	02910
Ensembl ID		ENSG00000111252	ENSG00000196498
Uniprot IDs		B7Z7K6 F5GYM4 Q59H48 Q96BA5 Q9UQQ2	C9J0Q5 C9JE98 Q9Y618
PDB IDs			1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX 6PDZ
Enriched GO Terms of Interacting Partners?
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