ACOT8 and PRDM16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ACOT8	PRDM16
Description		acyl-CoA thioesterase 8	PR/SET domain 16
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisomal Matrix Cytosol	Nucleus Nucleoplasm Cytosol Aggresome Transcription Repressor Complex
	Molecular Function	Acetyl-CoA Hydrolase Activity Succinyl-CoA Hydrolase Activity Protein Binding CoA Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Glutaryl-CoA Hydrolase Activity Acetoacetyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Hydroxymethylglutaryl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Medium-chain Acyl-CoA Hydrolase Activity Long-chain Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Histone-lysine N-methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) DNA-binding Transcription Factor Binding
	Biological Process	Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Fatty Acid Catabolic Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Dicarboxylic Acid Catabolic Process Negative Regulation Of CD4 Production	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Respiration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of Cold-induced Thermogenesis
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import	PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Allergic rhinitis ( 25085501) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiovascular disease in type 2 diabetes ( 33350037) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hypertension ( 31879980) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Myocardial infarction ( 33532862) Nicotine dependence symptom count ( 25555482) Nose morphology ( 29921221) Optic disc size ( 31809533) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 32888494 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		7 interacting genes: FBXO7 GRIN2A P4HA3 PEX5 PIK3CA PRDM16 REL	23 interacting genes: ACOT8 ARRB1 C5 CCDC13 CFAP206 DDX6 GLMN LENG8 LONRF1 MID2 MIPOL1 NEK6 PATJ PLK4 POLR3C RBBP4 RIOK2 RUNX1T1 TCHP TEX10 TSG101 TXLNA XPA
Entrez ID		10005	63976
HPRD ID		06998	16122
Ensembl ID		ENSG00000101473	ENSG00000142611
Uniprot IDs		A0A494C0N6 O14734	Q9HAZ2
PDB IDs			2N1I 6BW4
Enriched GO Terms of Interacting Partners?
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