HDAC4

Description		histone deacetylase 4
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Transcription Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Development Chromatin Remodeling Protein Deacetylation Inflammatory Response Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Smooth Muscle Cell Migration Histone Deacetylation Protein Sumoylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Regulation Of Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of DNA-binding Transcription Factor Activity Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of Male Mating Behavior Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX2 regulates chondrocyte maturation RUNX3 regulates p14-ARF
Drugs		Zinc Belinostat Romidepsin Panobinostat N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Body size at age 10 ( 32376654) Chronotype ( 30696823) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Diastolic blood pressure ( 30224653 30487518) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Heel bone mineral density ( 30598549) Intra-individual response time variability (selective attention) ( 30287865) Male-pattern baldness ( 22693459) Mean arterial pressure ( 29403010 30487518) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30487518)
Interacting Genes		123 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ASB15 ATF3 ATRX BCL6 BCOR BEGAIN BICD2 BLZF1 BORCS8-MEF2B BRMS1 CACNA1C CADPS CALCOCO2 CAMK4 CBX5 CCDC125 CCDC136 CCNDBP1 CDKN1A CDPF1 CDR2 CDR2L CEBPD CEP70 CIITA CSRP3 CTBP1 DYDC1 EFEMP2 EFHC2 ESR1 FCHSD2 FSD2 GATA1 GCM1 GOLGA2 GOLGA6L9 GRIPAP1 GSK3B HAP1 HDAC3 HDAC7 HDAC9 HNF4A HOOK2 HSF2BP IFRD1 IKZF2 INCA1 JDP2 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MID2 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBID NFKBIE NPPB NR1H2 NR2C1 NR2C2 PICK1 PNMA1 PPARD PPARG PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SSX2IP SUMO1 SUMO2 SYK TFIP11 TLE5 TNFRSF14 TRIB3 TRIM27 TSGA10 UBE2I VPS52 YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZMYND12 ZNF354A
Entrez ID		9759
HPRD ID		05610
Ensembl ID		ENSG00000068024
Uniprot IDs		A0A7I2SVS4 P56524
PDB IDs		2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ
Enriched GO Terms of Interacting Partners?
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