HPGD

Description		15-hydroxyprostaglandin dehydrogenase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Basolateral Plasma Membrane Extracellular Exosome
	Molecular Function	Prostaglandin E Receptor Activity 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding NAD Binding NAD+ Binding
	Biological Process	Kidney Development Prostaglandin Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Female Pregnancy Parturition Lipoxygenase Pathway Ovulation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Response To Ethanol Negative Regulation Of Cell Cycle Thrombin-activated Receptor Signaling Pathway Ductus Arteriosus Closure Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Prostaglandin Catabolic Process
Pathways		Synthesis of Lipoxins (LX) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Biosynthesis of D-series resolvins Biosynthesis of E-series 18(S)-resolvins
Drugs		NADH
Diseases
GWAS		Alcohol dependence ( 26365420) Metabolite levels ( 23823483) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		2 interacting genes: APP PRDM1
Entrez ID		3248
HPRD ID		03406
Ensembl ID		ENSG00000164120
Uniprot IDs		P15428
PDB IDs		2GDZ
Enriched GO Terms of Interacting Partners?
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