Respiratory - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
ECT2 and MT-CO2	epithelial cell transforming 2	cytochrome c oxidase subunit II	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	TP53 Regulates Metabolic Genes Respiratory electron transport		Cholic Acid N-Formylmethionine Talmapimod
EDN1 and EDNRA	endothelin 1	endothelin receptor type A	Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events	TBC-3711	Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Sitaxentan Ambrisentan Macitentan Sparsentan
EGFR and MT-CO2	epidermal growth factor receptor	cytochrome c oxidase subunit II	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants	TP53 Regulates Metabolic Genes Respiratory electron transport	Cetuximab Trastuzumab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE Afatinib Osimertinib Necitumumab Depatuxizumab mafodotin Icotinib Neratinib Zalutumumab Brigatinib Olmutinib	Cholic Acid N-Formylmethionine Talmapimod	Choriocarcinoma Gastric cancer Bladder cancer Oral cancer Glioma Laryngeal cancer Cervical cancer Esophageal cancer
ETFA and PSEN1	electron transfer flavoprotein subunit alpha	presenilin 1	Respiratory electron transport	Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	Acne inversa; Hidradenitis supprativa Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Alzheimer's disease (AD)
ETFA and MOV10L1	electron transfer flavoprotein subunit alpha	Mov10 like RISC complex RNA helicase 1	Respiratory electron transport	PIWI-interacting RNA (piRNA) biogenesis			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
ETFA and TNFRSF11A	electron transfer flavoprotein subunit alpha	TNF receptor superfamily member 11a	Respiratory electron transport	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD) Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
ETFA and FAH	electron transfer flavoprotein subunit alpha	fumarylacetoacetate hydrolase	Respiratory electron transport	Tyrosine catabolism		Fumaric Acid Acetoacetic Acid 4-[Hydroxy-[Methyl-Phosphinoyl]]-3-Oxo-Butanoic Acid	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
ETFA and HSPB2	electron transfer flavoprotein subunit alpha	heat shock protein family B (small) member 2	Respiratory electron transport				Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
ETFA and LINC00597	electron transfer flavoprotein subunit alpha	long intergenic non-protein coding RNA 597	Respiratory electron transport				Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
ETFA and VCAM1	electron transfer flavoprotein subunit alpha	vascular cell adhesion molecule 1	Respiratory electron transport	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling		Ethanol Carvedilol Succinobucol	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
ETFDH and HSD17B10	electron transfer flavoprotein dehydrogenase	hydroxysteroid 17-beta dehydrogenase 10	Respiratory electron transport	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol	NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
EWSR1 and NDUFB1	EWS RNA binding protein 1	NADH:ubiquinone oxidoreductase subunit B1		Respiratory electron transport Complex I biogenesis		NADH	Ewing's sarcoma Myxoid liposarcoma Clear cell sarcoma of soft tissue Extraskeletal myxoid chondrosarcoma
EYA1 and NDUFB9	EYA transcriptional coactivator and phosphatase 1	NADH:ubiquinone oxidoreductase subunit B9	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Respiratory electron transport Complex I biogenesis		NADH	Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
FAT1 and MT-ND1	FAT atypical cadherin 1	NADH dehydrogenase, subunit 1 (complex I)		Respiratory electron transport Complex I biogenesis		NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
FBN2 and NDUFB6	fibrillin 2	NADH:ubiquinone oxidoreductase subunit B6	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Respiratory electron transport Complex I biogenesis	Calcium Citrate Calcium Phosphate	NADH	Congenital contractural arachnodactyly (CCA) ; Beals syndrome
FDX1 and CYCS	ferredoxin 1	cytochrome c, somatic	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity	Mitotane	Minocycline Protoporphyrin Ix Containing Co Heme C Imidazole Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
XRCC6 and SDHC	X-ray repair cross complementing 6	succinate dehydrogenase complex subunit C	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Respiratory electron transport Citric acid cycle (TCA cycle)		Succinic acid 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol UBIQUINONE-1
GDF9 and NDUFB9	growth differentiation factor 9	NADH:ubiquinone oxidoreductase subunit B9		Respiratory electron transport Complex I biogenesis		NADH
GEM and NDUFAF3	GTP binding protein overexpressed in skeletal muscle	NADH:ubiquinone oxidoreductase complex assembly factor 3		Complex I biogenesis				Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GEM and SDHB	GTP binding protein overexpressed in skeletal muscle	succinate dehydrogenase complex iron sulfur subunit B		Respiratory electron transport Citric acid cycle (TCA cycle)		Succinic acid 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol UBIQUINONE-1

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