ETFA and TNFRSF11A

		ETFA	TNFRSF11A
Description		electron transfer flavoprotein subunit alpha	TNF receptor superfamily member 11a
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Positive Regulation Of Bone Resorption Lymph Node Development Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Multinuclear Osteoclast Differentiation
Pathways		Respiratory electron transport	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency	Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD) Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Diverticular disease ( 30177863) Glioma ( 28346443) Heel bone mineral density ( 30598549) Non-glioblastoma glioma ( 28346443 26424050) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576 29875488) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Myasthenia gravis ( 25643325) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100) Serum alkaline phosphatase levels ( 29403010) Vitiligo ( 27723757)
Interacting Genes		14 interacting genes: BNC1 CDC42 CHRNA3 COX7C CSK CYP11A1 ETFB FAH HSPB2 LINC00597 MOV10L1 PSEN1 TNFRSF11A VCAM1	14 interacting genes: CBL CBLB ETFA FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		2108	8792
HPRD ID		01979	04609
Ensembl ID		ENSG00000140374	ENSG00000141655
Uniprot IDs		A0A0S2Z3L0 P13804	Q9Y6Q6
PDB IDs		1EFV 1T9G 2A1T 2A1U	1LB5
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?