Respiratory - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
CACNA1A and UQCRC2	calcium voltage-gated channel subunit alpha1 A	ubiquinol-cytochrome c reductase core protein 2	Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Respiratory electron transport	Pregabalin Spironolactone Verapamil Loperamide Bepridil	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE FAMOXADONE METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE UBIQUINONE-2	Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
CAPN1 and NDUFB7	calpain 1	NADH:ubiquinone oxidoreductase subunit B7	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Respiratory electron transport Complex I biogenesis	N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine CBZ-LEU-LEU-TYR-CH2F (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	NADH
CASP9 and CYCS	caspase 9	cytochrome c, somatic	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity		Minocycline Protoporphyrin Ix Containing Co Heme C Imidazole Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
CCNG1 and MT-CO2	cyclin G1	cytochrome c oxidase subunit II	Regulation of TP53 Degradation	TP53 Regulates Metabolic Genes Respiratory electron transport		Cholic Acid N-Formylmethionine Talmapimod
CDC42 and ETFA	cell division cycle 42	electron transfer flavoprotein subunit alpha	GPVI-mediated activation cascade EGFR downregulation Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Respiratory electron transport	Aminophosphonic Acid-Guanylate Ester Guanosine-5'-Diphosphate			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
CDC42 and MT-CO1	cell division cycle 42	cytochrome c oxidase subunit I	GPVI-mediated activation cascade EGFR downregulation Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	TP53 Regulates Metabolic Genes Respiratory electron transport	Aminophosphonic Acid-Guanylate Ester Guanosine-5'-Diphosphate	Cholic Acid N-Formylmethionine Oxygen		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
CDR2 and COX5B	cerebellar degeneration related protein 2	cytochrome c oxidase subunit 5B		TP53 Regulates Metabolic Genes Respiratory electron transport		Cholic Acid N-Formylmethionine
CD52 and LMNA	CD52 molecule	lamin A/C	Post-translational modification: synthesis of GPI-anchored proteins	XBP1(S) activates chaperone genes Signaling by BRAF and RAF fusions	Alemtuzumab			Restrictive dermopathy Emery-Dreifuss muscular dystrophy Dilated cardiomyopathy (DCM) Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Mandibuloacral dysplasia Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Limb-girdle muscular dystrophy (LGMD) Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Hutchinson-Gilford progeria syndrome
CHRNA3 and ETFA	cholinergic receptor nicotinic alpha 3 subunit	electron transfer flavoprotein subunit alpha	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Respiratory electron transport	Nicotine Dextromethorphan Galantamine Levamisole Ethanol Pentolinium Bupropion Levomethadyl Acetate Varenicline Epibatidine Cytisine			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
COL6A1 and COL6A2	collagen type VI alpha 1 chain	collagen type VI alpha 2 chain	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization			Ossification of the posterior longitudinal ligament of spine (OPLL) Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
COL6A2 and COX6A2	collagen type VI alpha 2 chain	cytochrome c oxidase subunit 6A2	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization			Cholic Acid N-Formylmethionine	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
COX4I1 and SDCBP	cytochrome c oxidase subunit 4I1	syndecan binding protein	TP53 Regulates Metabolic Genes Respiratory electron transport	Ephrin signaling Neurofascin interactions Neutrophil degranulation	Cholic Acid N-Formylmethionine
COX5B and TRAF1	cytochrome c oxidase subunit 5B	TNF receptor associated factor 1	TP53 Regulates Metabolic Genes Respiratory electron transport	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway	Cholic Acid N-Formylmethionine
COX5B and PNMA1	cytochrome c oxidase subunit 5B	PNMA family member 1	TP53 Regulates Metabolic Genes Respiratory electron transport		Cholic Acid N-Formylmethionine
COX5B and KRT15	cytochrome c oxidase subunit 5B	keratin 15	TP53 Regulates Metabolic Genes Respiratory electron transport	Keratinization Formation of the cornified envelope	Cholic Acid N-Formylmethionine
COX5B and MID2	cytochrome c oxidase subunit 5B	midline 2	TP53 Regulates Metabolic Genes Respiratory electron transport		Cholic Acid N-Formylmethionine
COX5B and LSM4	cytochrome c oxidase subunit 5B	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	TP53 Regulates Metabolic Genes Respiratory electron transport	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	Cholic Acid N-Formylmethionine
COX5B and KRT31	cytochrome c oxidase subunit 5B	keratin 31	TP53 Regulates Metabolic Genes Respiratory electron transport	Keratinization Formation of the cornified envelope	Cholic Acid N-Formylmethionine
COX5B and TFIP11	cytochrome c oxidase subunit 5B	tuftelin interacting protein 11	TP53 Regulates Metabolic Genes Respiratory electron transport	mRNA Splicing - Major Pathway	Cholic Acid N-Formylmethionine
COX5B and TASOR2	cytochrome c oxidase subunit 5B	transcription activation suppressor family member 2	TP53 Regulates Metabolic Genes Respiratory electron transport		Cholic Acid N-Formylmethionine

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