Respiratory - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
MT-ND3 and ABHD16A	NADH dehydrogenase, subunit 3 (complex I)	abhydrolase domain containing 16A, phospholipase	Respiratory electron transport Complex I biogenesis		NADH
MT-ND4 and CTCF	NADH dehydrogenase, subunit 4 (complex I)	CCCTC-binding factor	Respiratory electron transport Complex I biogenesis	Activation of anterior HOX genes in hindbrain development during early embryogenesis	NADH		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND4 and NKX3-1	NADH dehydrogenase, subunit 4 (complex I)	NK3 homeobox 1	Respiratory electron transport Complex I biogenesis		NADH		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND4 and ABHD16A	NADH dehydrogenase, subunit 4 (complex I)	abhydrolase domain containing 16A, phospholipase	Respiratory electron transport Complex I biogenesis		NADH		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MTNR1B and SDHD	melatonin receptor 1B	succinate dehydrogenase complex subunit D	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Respiratory electron transport Citric acid cycle (TCA cycle)	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon	Succinic acid Hexachlorophene 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol	Type II diabetes mellitus	Carcinoid
NAB2 and TTC19	NGFI-A binding protein 2	tetratricopeptide repeat domain 19	NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
NCF2 and NCF4	neutrophil cytosolic factor 2	neutrophil cytosolic factor 4	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	Dextromethorphan	Dextromethorphan	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
NCF2 and RAC1	neutrophil cytosolic factor 2	Rac family small GTPase 1	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Factors involved in megakaryocyte development and platelet production	Dextromethorphan	Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
NCF2 and RAC2	neutrophil cytosolic factor 2	Rac family small GTPase 2	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Dextromethorphan	Dextromethorphan	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
NCF4 and NCF1	neutrophil cytosolic factor 4	neutrophil cytosolic factor 1	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	Dextromethorphan	Dextromethorphan		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
NDN and PPARGC1A	necdin, MAGE family member	PPARG coactivator 1 alpha	Interleukin-4 and Interleukin-13 signaling	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Circadian Clock Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
NDUFA2 and LINC00839	NADH:ubiquinone oxidoreductase subunit A2	long intergenic non-protein coding RNA 839	Respiratory electron transport Complex I biogenesis		NADH
NDUFA2 and NSG2	NADH:ubiquinone oxidoreductase subunit A2	neuronal vesicle trafficking associated 2	Respiratory electron transport Complex I biogenesis		NADH
NDUFA4 and PARK7	NDUFA4 mitochondrial complex associated	Parkinsonism associated deglycase	TP53 Regulates Metabolic Genes Respiratory electron transport	SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	NADH	Copper		Parkinson's disease (PD)
NDUFA4 and FBLN5	NDUFA4 mitochondrial complex associated	fibulin 5	TP53 Regulates Metabolic Genes Respiratory electron transport	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	NADH			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
NDUFA5 and COG6	NADH:ubiquinone oxidoreductase subunit A5	component of oligomeric golgi complex 6	Respiratory electron transport Complex I biogenesis	COPI-mediated anterograde transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	NADH
NDUFA5 and CBY2	NADH:ubiquinone oxidoreductase subunit A5	chibby family member 2	Respiratory electron transport Complex I biogenesis		NADH
NDUFA5 and DAZAP2	NADH:ubiquinone oxidoreductase subunit A5	DAZ associated protein 2	Respiratory electron transport Complex I biogenesis		NADH
NDUFA5 and CCDC85B	NADH:ubiquinone oxidoreductase subunit A5	coiled-coil domain containing 85B	Respiratory electron transport Complex I biogenesis		NADH
NDUFA6 and TBPL1	NADH:ubiquinone oxidoreductase subunit A6	TATA-box binding protein like 1	Respiratory electron transport Complex I biogenesis		NADH

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