CASP8AP2 and GLUL

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		CASP8AP2	GLUL
Description		caspase 8 associated protein 2	glutamate-ammonia ligase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body	Nucleus Mitochondrion Rough Endoplasmic Reticulum Cytosol Plasma Membrane Protein-containing Complex Perikaryon Myelin Sheath Axon Terminus Extracellular Exosome Glial Cell Projection
	Molecular Function	DNA Binding Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding	Magnesium Ion Binding Glutamate-ammonia Ligase Activity Protein Binding ATP Binding Glutamate Binding Protein-cysteine S-palmitoyltransferase Activity Manganese Ion Binding Identical Protein Binding Dynein Light Chain Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription	Neurotransmitter Uptake Angiogenesis Glutamate Catabolic Process Glutamine Biosynthetic Process Cell Proliferation Cellular Amino Acid Biosynthetic Process Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ammonia Assimilation Cycle Positive Regulation Of Insulin Secretion Ribosome Biogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus
Pathways		SUMOylation of transcription cofactors	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs			L-Glutamine Glutamic Acid
Diseases			Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder ( 29317602)	Cardiovascular heart disease in diabetics ( 23982368) Morning person ( 30696823)
Interacting Genes		17 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL MX1 NR3C2 PML SP100 SREBF2 TRAF2 TRIM21 UBE2I	22 interacting genes: CASP8AP2 CRBN CYP39A1 DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL TAT UBE2I
Entrez ID		9994	2752
HPRD ID		06048	00701
Ensembl ID		ENSG00000118412	ENSG00000135821
Uniprot IDs		Q9UKL3	A8YXX4 P15104
PDB IDs		2LR8 6ANO 6AOZ 6AP0	2OJW 2QC8
Enriched GO Terms of Interacting Partners?
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