OXSR1 and SLC12A1

Number of citations of the paper that reports this interaction (PubMedID 12386165)
138

Data Source:
HPRD (two hybrid)

		OXSR1	SLC12A1
Description		oxidative stress responsive kinase 1	solute carrier family 12 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cell Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding	Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity
	Biological Process	Protein Phosphorylation Response To Oxidative Stress Osmosensory Signaling Pathway Regulation Of Mitotic Cell Cycle Positive Regulation Of T Cell Chemotaxis Peptidyl-threonine Phosphorylation Signal Transduction By Protein Phosphorylation Signal Transduction By Trans-phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Chemokine	Ion Transport Cell Volume Homeostasis Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Drugs			Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium Chloride Hydroflumethiazide Bumetanide Etacrynic acid Trichlormethiazide Quinethazone Piretanide
Diseases			Bartter syndrome
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)	Metabolite levels (Pyroglutamine) ( 23934736) Systemic lupus erythematosus ( 26606652)
Interacting Genes		10 interacting genes: APP BMPR1B GORASP1 PAK1 RELL1 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1	3 interacting genes: OXSR1 STK39 TCF12
Entrez ID		9943	6557
HPRD ID		06809	02908
Ensembl ID		ENSG00000172939	ENSG00000074803
Uniprot IDs		O95747	B4DPF4 Q13621 Q8IUN5
PDB IDs		2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?
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