CDC20 and KIF18A

Number of citations of the paper that reports this interaction (PubMedID 23288039)
31

Data Source:
BioGRID (enzymatic study)

		CDC20	KIF18A
Description		cell division cycle 20	kinesin family member 18A
Image
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Anaphase-promoting Complex Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm	Kinetochore Ruffle Cell Nucleus Cytoplasm Microtubule Organizing Center Kinetochore Microtubule Cytosol Kinesin Complex Microtubule Caveola Microtubule Cytoskeleton Mitotic Spindle Astral Microtubule Mitotic Spindle Midzone
	Molecular Function	Protein Binding Protein C-terminus Binding Anaphase-promoting Complex Binding Enzyme Binding Histone Deacetylase Binding Ubiquitin-protein Transferase Activator Activity	Microtubule Motor Activity Actin Binding Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Microtubule Plus-end Binding Tubulin-dependent ATPase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Protein Ubiquitination Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Regulation Of Dendrite Development Cell Division Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Mitotic Sister Chromatid Segregation Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Microtubule Depolymerization Mitotic Metaphase Plate Congression Male Meiotic Nuclear Division Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Estradiol Stimulus Seminiferous Tubule Development
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins Kinesins
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598)	Chloride levels ( 29403010) Fulminant type 1 diabetes ( 30552108) Metabolite levels ( 23823483)
Interacting Genes		46 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CCT5 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L1BP MAD2L2 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 TP63 TRIP13 UBC UBE2C UBE2S	2 interacting genes: CDC20 PPP1CA
Entrez ID		991	81930
HPRD ID		04686	11177
Ensembl ID		ENSG00000117399	ENSG00000121621
Uniprot IDs		Q12834	Q8NI77
PDB IDs		4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H	3LRE 5OAM 5OCU 5OGC
Enriched GO Terms of Interacting Partners?
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