SV2A and LAMA5

Number of citations of the paper that reports this interaction (PubMedID 10617638)
13

Data Source:
HPRD (in vivo)

		SV2A	LAMA5
Description		synaptic vesicle glycoprotein 2A	laminin subunit alpha 5
Image
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Synaptic Vesicle Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite Synaptic Vesicle Membrane Neuromuscular Junction Neuron Projection Neuronal Cell Body Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Kinase Binding Transmembrane Transporter Activity	Integrin Binding Extracellular Matrix Structural Constituent
	Biological Process	Cellular Calcium Ion Homeostasis Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Priming Transmembrane Transport	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Integrin-mediated Signaling Pathway Muscle Organ Development Animal Organ Morphogenesis Tissue Development Morphogenesis Of Embryonic Epithelium Cell Migration Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Extracellular Matrix Organization Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Cell-cell Adhesion
Pathways		Toxicity of botulinum toxin type D (BoNT/D) Toxicity of botulinum toxin type A (BoNT/A) Toxicity of botulinum toxin type F (BoNT/F) Toxicity of botulinum toxin type E (BoNT/E)	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling
Drugs		Levetiracetam Brivaracetam Seletracetam
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Height ( 25429064 31562340 18391951) Lung function (FEV1) ( 26635082)	Blood protein levels ( 29875488) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Pelvic organ prolapse ( 26545240) Prostate cancer ( 23535732)
Interacting Genes		3 interacting genes: ATXN1 DNAJC5 LAMA5	15 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4
Entrez ID		9900	3911
HPRD ID		08922	03020
Ensembl ID		ENSG00000159164	ENSG00000130702
Uniprot IDs		B4E000 Q7L0J3	O15230
PDB IDs		4V11	5XAU
Enriched GO Terms of Interacting Partners?
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