PLEKHM1 and SERPINB9

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLEKHM1	SERPINB9
Description		pleckstrin homology and RUN domain containing M1	serpin family B member 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Lysosomal Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Extracellular Space Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Metal Ion Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Autophagy Protein Transport Lysosome Localization Intracellular Signal Transduction Positive Regulation Of Bone Resorption Positive Regulation Of Ruffle Assembly	Mast Cell Mediated Immunity Apoptotic Process Immune Response Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Endopeptidase Activity Negative Regulation By Symbiont Of Host Apoptotic Process Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Estrogen Stimulus
Pathways
Drugs			Raloxifene
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Cognitive function ( 28093568) Epithelial ovarian cancer ( 25581431) Hip circumference ( 28552196) Male-pattern baldness ( 29146897 28196072) Neuroticism ( 29255261) Parkinson's disease ( 20070850) Remission after SSRI treatment in MDD or neuroticism ( 29559929)	Vitiligo ( 27723757)
Interacting Genes		8 interacting genes: BID EIF2S2 GADD45G MAPK6 MOB4 MUC2 PAFAH1B3 SERPINB9	28 interacting genes: BRD7 CASP1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 ERG28 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1
Entrez ID		9842	5272
HPRD ID		11439	03480
Ensembl ID		ENSG00000225190	ENSG00000170542
Uniprot IDs		Q9Y4G2	A0A024QZT4 P50453
PDB IDs		5DPR 5DPS 5DPT 5DPW
Enriched GO Terms of Interacting Partners?
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