SPOCK2 and SPOCK3

Number of citations of the paper that reports this interaction (PubMedID 12810672)
16

Data Source:
HPRD (in vitro)

		SPOCK2	SPOCK3
Description		SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Extracellular Matrix	Extracellular Space
	Molecular Function	Calcium Ion Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Binding	Calcium Ion Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Binding
	Biological Process	Synapse Assembly Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Regulation Of Cell Differentiation Anatomical Structure Development Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell Motility	Negative Regulation Of Endopeptidase Activity Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Anatomical Structure Development Negative Regulation Of Cell Motility
Pathways			Activation of Matrix Metalloproteinases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Insulin-like growth factors ( 21216879) Smoking behavior ( 22832964)	Blood protein levels ( 30072576 29875488) Cognitive function ( 28808816) Immune reponse to smallpox (secreted IL-10) ( 22610502) Medial orbital frontal cortex volume ( 31530798) Obesity-related traits ( 23251661) Verbal declarative memory ( 25648963) Weight ( 28552196)
Interacting Genes		3 interacting genes: PLXNB3 SPOCK3 TES	4 interacting genes: CREB3 MMP14 MMP3 SPOCK2
Entrez ID		9806	50859
HPRD ID		12146	12147
Ensembl ID		ENSG00000107742	ENSG00000196104
Uniprot IDs		A0A024QZQ5 Q92563	A0A0A0MTJ2 B4DI52 Q9BQ16
PDB IDs
Enriched GO Terms of Interacting Partners?
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