TOMM20 and DHFR

Number of citations of the paper that reports this interaction (PubMedID 9119086)
8

Data Source:
HPRD (in vitro)

		TOMM20	DHFR
Description		translocase of outer mitochondrial membrane 20	dihydrofolate reductase
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Integral Component Of Mitochondrial Outer Membrane Mitochondria-associated ER Membrane	Mitochondrion Cytosol
	Molecular Function	Protein Binding P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding	Translation Repressor Activity, MRNA Regulatory Element Binding MRNA Binding Dihydrofolate Reductase Activity Folic Acid Binding Drug Binding NADP Binding Methotrexate Binding NADPH Binding Sequence-specific MRNA Binding
	Biological Process	Protein Targeting To Mitochondrion Response To Muscle Activity TRNA Import Into Mitochondrion Macroautophagy Protein Deubiquitination Protein Import Into Mitochondrial Matrix Mitochondrial Outer Membrane Translocase Complex Assembly Response To 3,3',5-triiodo-L-thyronine	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Tetrahydrobiopterin Biosynthetic Process One-carbon Metabolic Process Negative Regulation Of Translation Axon Regeneration Response To Methotrexate Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Oxidation-reduction Process Regulation Of Removal Of Superoxide Radicals
Pathways		Mitochondrial protein import Pink/Parkin Mediated Mitophagy Ub-specific processing proteases	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Metabolism of folate and pterines G1/S-Specific Transcription
Drugs			NADH Pyrimethamine Trimethoprim Methotrexate Pemetrexed Gentamicin Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 2'-Monophosphoadenosine 5'-Diphosphoribose Piritrexim Biopterin 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS		Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661)	Glomerular filtration rate (creatinine) ( 26831199) Huntington's disease progression ( 28642124) Shingles ( 25297839)
Interacting Genes		19 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PPHLN1 PTN TOMM22 TOMM40 UCP1 VDAC1	9 interacting genes: AMFR ASGR1 FKBP1A GKAP1 HSPD1 MDM2 THBS1 TOMM20 TP53
Entrez ID		9804	1719
HPRD ID		03507	00519
Ensembl ID		ENSG00000173726	ENSG00000228716
Uniprot IDs		A0A024R3W2 Q15388	B0YJ76 B4DM58 P00374
PDB IDs		4APO	1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4G95 4KAK 4KBN 4KD7 4KEB 4KFJ 4M6J 4M6K 4M6L 4QHV 4QJC 5HPB 5HQY 5HQZ 5HSR 5HSU 5HT4 5HT5 5HUI 5HVB 5HVE 6A7C 6A7E 6DAV 6DE4
Enriched GO Terms of Interacting Partners?
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