HDAC4 and CDR2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HDAC4	CDR2
Description		histone deacetylase 4	cerebellar degeneration related protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Transcriptional Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin	Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Development Chromatin Remodeling Protein Deacetylation Inflammatory Response Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Smooth Muscle Cell Migration Histone Deacetylation Protein Sumoylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of DNA-binding Transcription Factor Activity Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of Male Mating Behavior Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX2 regulates chondrocyte maturation RUNX3 regulates p14-ARF
Drugs		Zinc Belinostat Romidepsin Panobinostat N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL
Diseases		Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653 30487518) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Heel bone mineral density ( 30598549) Intra-individual response time variability (selective attention) ( 30287865) Male-pattern baldness ( 22693459) Mean arterial pressure ( 29403010 30487518) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30487518)
Interacting Genes		88 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ATF3 ATRX BCL6 BCOR BRMS1 CACNA1C CAMK4 CBX5 CCDC136 CDKN1A CDR2 CEBPD CIITA CSRP3 CTBP1 EFEMP2 ESR1 GATA1 GCM1 GNB1 GOLGA2 GSK3B HDAC3 HDAC7 HDAC9 HNF4A IFRD1 IKZF2 JDP2 KRT31 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBIE NPPB NR1H2 NR2C1 NR2C2 NUP155 PNMA1 PPARD PPARG PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SUMO1 SUMO2 SYK TNFRSF14 UBE2I YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZNF354A	43 interacting genes: AMOTL2 ANKRD36BP1 ARNT2 C1orf216 C2CD6 C4orf46 CCDC153 CCHCR1 CDC20 CEP57L1 CHIC2 COX5B EIF4E2 ELOB ENKD1 FAM110A FAM161A FZR1 GMPPA HAUS1 HDAC4 HGS KANSL1 KIFC3 LENG1 LIN37 MORF4L2 MRPL28 NDN NTAQ1 PKN1 RCOR3 RSPH14 SCNM1 SH2D4A SMARCE1 TBC1D22B TCHP TMCC2 TRIM23 TTR TXLNA ZGPAT
Entrez ID		9759	1039
HPRD ID		05610	06681
Ensembl ID		ENSG00000068024	ENSG00000140743
Uniprot IDs		P56524	Q01850
PDB IDs		2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ
Enriched GO Terms of Interacting Partners?
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