GPRASP1 and F2RL1

Number of citations of the paper that reports this interaction (PubMedID 15452121)
66

Data Source:
HPRD (in vitro)

		GPRASP1	F2RL1
Description		G protein-coupled receptor associated sorting protein 1	F2R like trypsin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cell Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Pseudopodium
	Molecular Function	Protein Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding Signaling Receptor Activity
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Glomerular Filtration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Rho Protein Signal Transduction Chemokine (C-C Motif) Ligand 2 Secretion Neutrophil Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Eosinophil Degranulation Positive Regulation Of GTPase Activity Innate Immune Response Cell-cell Junction Maintenance Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Interleukin-1 Beta Secretion Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Defense Response To Virus Positive Regulation Of Phagocytosis, Engulfment Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Leukocyte Proliferation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Interleukin-10 Secretion Interferon-gamma Secretion Chemokine Secretion Negative Regulation Of Chemokine Secretion Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Blood Vessel Diameter Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS			Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171)
Interacting Genes		47 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	21 interacting genes: ANKRA2 CAPN1 CAPN2 CBL COPS5 CTSG CYFIP2 DNMT3L ELANE F2 F2R GPRASP1 JMY LMNA MAP1B NUMA1 PCBD2 PLG PRTN3 RAD17 ST14
Entrez ID		9737	2150
HPRD ID		02333	02960
Ensembl ID		ENSG00000198932	ENSG00000164251
Uniprot IDs		Q5JY77	P55085
PDB IDs			5NDD 5NDZ 5NJ6
Enriched GO Terms of Interacting Partners?
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