NOS1AP and SYN1

Number of citations of the paper that reports this interaction (PubMedID 11867766)
32

Data Source:
HPRD (in vivo)

		NOS1AP	SYN1
Description		nitric oxide synthase 1 adaptor protein	synapsin I
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Caveola Z Disc T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Perinuclear Region Of Cytoplasm Glutamatergic Synapse Inward Rectifier Potassium Channel Complex L-type Voltage-gated Calcium Channel Complex	Synaptonemal Complex Golgi Apparatus Cytosol Cytoskeleton Synaptic Vesicle Postsynaptic Density Cell Junction Axon Dendrite Synaptic Vesicle Membrane Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Extrinsic Component Of Synaptic Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Nitric-oxide Synthase Binding	Actin Binding Transporter Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
Drugs			Adenosine 5'-[Î³-thio]triphosphate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Body mass index (change over time) ( 25133637) Electrocardiographic traits ( 20062061 20062063 25055868) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) QT interval ( 23166209 30679814 20031603 29213071 16648850 24952745 22726844 19305408 19305409 19587794) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Word reading ( 23738518)
Interacting Genes		20 interacting genes: AKNAD1 APP CKM CT45A5 FAM133A FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		9722	6853
HPRD ID		12023	02433
Ensembl ID		ENSG00000198929	ENSG00000008056
Uniprot IDs		O75052	P17600
PDB IDs
Enriched GO Terms of Interacting Partners?
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