CD74 and CD1D

Number of citations of the paper that reports this interaction (PubMedID 11754812)
70

Data Source:
HPRD (in vivo)

		CD74	CD1D
Description		CD74 molecule	CD1d molecule
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Space Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Basolateral Plasma Membrane
	Molecular Function	Amyloid-beta Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding CD4 Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Binding Involved In Protein Folding Nitric-oxide Synthase Binding	Protein Binding Beta-2-microglobulin Binding Lipid Antigen Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Histone Binding Cell Adhesion Molecule Binding Lipopeptide Binding
	Biological Process	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Intracellular Protein Transport Defense Response Cell Proliferation Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Kinase Activity Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of Macrophage Cytokine Production Protein-containing Complex Assembly Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response Detection Of Bacterium Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation T Cell Selection Innate Immune Response Positive Regulation Of Innate Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of Immune Response
Pathways		Cell surface interactions at the vascular wall MHC class II antigen presentation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Cis-tetracosenoyl sulfatide
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Post bronchodilator FEV1/FVC ratio ( 26634245)	Dental caries (decayed and filled deciduous teeth) ( 31533690)
Interacting Genes		16 interacting genes: APP CD1D CD44 CTSF CTSL HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA LAMTOR5 MAP3K1 MIF	7 interacting genes: B2M CALR CANX CD74 P4HB PTPRC TRB
Entrez ID		972	912
HPRD ID		00825	01780
Ensembl ID		ENSG00000019582	ENSG00000158473
Uniprot IDs		P04233	P15813
PDB IDs		1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W 5KSU 5KSV	1ZT4 2PO6 3HUJ 3SDX 3TZV 3U0P 3VWJ 3VWK 4EN3 4LHU 4MNG 4MQ7 4WO4 4WW2 4WWK
Enriched GO Terms of Interacting Partners?
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