CD58 and HERPUD1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CD58	HERPUD1
Description		CD58 molecule	homocysteine inducible ER protein with ubiquitin like domain 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Lewy Body Core
	Molecular Function	Signaling Receptor Binding Protein Binding	Molecular_function Protein Binding Ion Channel Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination
	Biological Process	Heterotypic Cell-cell Adhesion Neutrophil Degranulation Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Positive Regulation Of Interleukin-8 Secretion	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation	ATF4 activates genes in response to endoplasmic reticulum stress
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244 22190364 21244703 24076602 19525953 19525955 21833088 27386562) Primary biliary cholangitis ( 28425483)	Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Total cholesterol levels ( 29403010) Triglyceride levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		4 interacting genes: APP CD2 DNAJA1 HERPUD1	16 interacting genes: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 VCP XRCC6
Entrez ID		965	9709
HPRD ID		01081	07456
Ensembl ID		ENSG00000116815	ENSG00000051108
Uniprot IDs		P19256	A4UAE9 Q15011 Q53FP9
PDB IDs		1CCZ 1CI5 1QA9	1WGD
Enriched GO Terms of Interacting Partners?
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